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KMID : 0361720130240010029
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Korean Journal of perinatology
2013 Volume.24 No. 1 p.29 ~ p.36
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Clinical Efficacy of Recombinant Activated Factor VII in Postpartum Hemorrhage
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Moon Soo-Hyeon
Kim Seung-Chul
Joo Jong-Kil
Suh Dong-Soo
Lee Dong-Hyung
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Abstract
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Purpose: This study was aimed to investigate the clinical efficacy of recombinant activated factor VII (rFVIIa) for patients with intractable postpartum hemorrhage. Methods: This was a retrospective study of ten patients who were treated with rFVIIa from July 2010 to February 2012 in one tertiary center. To evaluate each case, we used a standardized case record form. The primary outcome measures were response of rFVIIa, reduction of blood product requirement, changes of coagulation parameter. The response of rFVIIa was categorized to three groups: “complete responder”, “partial responder”, “poor responder”. Results: After the administration of rFVIIa, effect for bleeding was completely responded in 4 patients, partially responded in 6 patients, and poorly responded in none. A certain amount of reduction in blood product requirements was noted following rFVIIa administration, although no significant differences were observed statistically between before and after rFVIIa administration except RBC (P<0.01). Fibrinogen and INR were significantly reduced in all case types, but other coagulation parameters were not (P<0.01). Conclusion: The present results suggest that rFVIIa is a beneficial therapeutic option that could reduce blood loss and contribute to reduction of maternal morbidities and mortalities in patients with massive postpartum hemorrhage.
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KEYWORD
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Recombinant activated factor 7, Clinical efficacy, Postpartum hemorrhage
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